Recent Publications:

Mar, J., Makhijani, K., Flaherty, D., and Bhat, K.M. (2022). Nuclear Prospero allows one- division potential to neural precursors and post-mitotic status to neurons via opposite regulation of Cyclin E. PLoS Genet. In press.

Bhat, A., Ghatage, T., Bhan, S., Lahane, G.P., Dhar, A., Kumar, R., Pandita, R.K., Bhat, K.M., Ramos, K.S., and Pandita, T.K. Role of Transposable Elements in Genome Stability: Implications for Health and Disease. Int. J. Mol. Sci. 2022, 23, 7802.

Chakraborty, S., Singh, M., Pandita, R.K., Singh, V., Calvin, S., Lo, C., Leonard, F., Nobuo Horikoshi, N., Moros, E.G., Guha, D., Hunt, C. R., Makhijani, K., Chau, E., Ahmed, K.M., Sethi, P., Charaka, V., Godin, B., Scherthan, B., Deck, J., Hausmann, M., Mushtaq, A., Altaf, M., Ramos, K.S., Bhat, K.M., Taneja, N., Das, C., and Pandita, T.K. (2021). Heat-induced SIRT1- mediated H4K16ac deacetylation impairs resection and SMARCAD1 recruitment to double strand breaks. iScience 25, 104142, April 15, 2022.

Myers, J.L., Porter, M., Narwold, N., Bhat, K.M., Dauwalder, B., Roman, G. (2021). Mutants of the white ABCG transporter in Drosophila melanogaster have deficient olfactory learning and cholesterol homeostasis. Int. J. Mol. Sci. 2021, 22, x.

Gaziova I, Gazi M, Mar J, Bhat KM. (2020). Restriction on self-renewing asymmetric division is coupled to terminal asymmetric division and is mediated by Midline and Cyclin E. PLoS Genet 16(9): e1009011.

Murashov, A., Pak, E., Lin, C-T., Boykov, I., Buddo, K. A., Mar, J., Bhat, K. M., Neufer, P. D. (2020). Preference and detrimental effects of high fat, sugar and salt diet in wild-caught Drosophila simulans are reversed by flight exercise. FASEB BioAdvances 00:1-16.

Bhat, K. M. (2017). Post-guidance signaling by extracellular matrix-associated Slit/Slit-N maintains fasciculation and position of axon tracts in the nerve cord. PLoS Genet. 2017 Nov 20;13(11):e1007094. doi: 10.1371/journal.pgen.1007094. eCollection 2017 Nov. PubMed PMID: 29155813; PubMed Central PMCID: PMC5714384.

Manavalan, M. A., Jayasinghe, V. R., Grewal, R., Bhat, K. M. (2017). The glycosylation pathway is required for the secretion of Slit and for the maintenance of the Slit receptor Robo on axons. Science Signaling, 10(484), [eaam5841]. DOI: 10.1126/scisignal.aam5841

Bhat, K. M. (2014). Notch specifies asymmetric cleavage and cell fate at the pre-mitotic precursor stage. Science signaling. 7, ra101. *cover article and accompanied by a “Perspectives” article by Prof. Claude Desplan, academic editor for Science.

Manavalan, M., Gaziova, I., Bhat K. M. (2013). The Midline protein regulates axon guidance by blocking reiteration of neuroblast rows within the ventral nerve cord. PLoS Genetics, 9(12): e1004050. doi:10.1371/journal.pgen.1004050.

Poddighe, S., Bhat, K.M, Angiovy, A.M, Marrosu, F., Lucia, A.M. (2013). Impaired sense of smell in a Drosophila Parkinson's model. PLoS ONE 8(8), e73156. doi:10.1371/journal.pone.0073156.

Bhat, K. M., Gaziova, I., Katipalla, S. (2011). Neuralized mediates asymmetric division of neural precursors by two distinct and sequential events: promoting asymmetric localization of Numb and enhancing activation of Notch-signaling. Dev. Biol. 351: 186–198.

Zhu, Z., and Bhat, K. M. (2011). The Drosophila Hem protein regulates asymmetric division upstream of Notch via regulating Inscuteable localization. Mech Dev. 128:483-95.

Zhu, Z., Bhat, K.M. (2011). The Hem protein mediates neuronal migration by inhibiting WAVE degradation and functions opposite of Abelson tyrosine kinase. Dev Biol. 2011 Sep 15;357(2):283-94.

Hafer, N., Xu, S., Bhat, K. M., Schedl, P. (2011). The Drosophila CPEB Protein Orb2 Has a Novel Expression Pattern and is Important for Asymmetric Cell Division and Nervous System Function. Genetics 189: 907-21.

Apsel, N., Ruiu, E., Bhat, K. M. (2011). Absence of mutagenic activity of vitamin C in vivo in Drosophila The Open Cell Development & Biology Journal 3: 6-9.

Carta, M.G., Tondo, L., Balestrieri, M., Caraci, F., Osso, L., Di Sciascio, G., Faravelli, C., Carolina, M., Hardoy, M.C., Lecca, E., Moro, M. F., Bhat, K. M., Casacchia, M., Drago, F. (2011). Sub-threshold depression and antidepressants use in a community sample: searching anxiety and finding bipolar disorder. BMC Psychiatry 11:164.

Gaziova, I., Bhat, K. M. (2009). Ancestry-independent fate specification and plasticity in the developmental timing of a typical Drosophila neuronal lineage. Development 136: 263-274.

Gazi, M., Shyamala, B. V., Bhat, K. M. (2009). The tumor suppressor protein Patched regulates synaptic connections via cholesterol in the adult brain and suppresses a neural disease in Drosophila. Dev. Biol. 334: 311-323.

Bhat, K. M., Gaziova, I., Krishnan, S. (2007). Regulation of Axon guidance by Slit and Netrin signaling in the Drosophila ventral nerve cord. Genetics 176: 2235-2246.

Bhat, K. M. (2007). Neuronal migratory pattern is determined at the precursor cell stage and is necessary for the proper axon projection in the Drosophila nerve cord. Dev. Biol. 311: 613-622.

Gaziova, I., Bhat, K. M. (2006). Generating Asymmetry: with and without self-renewal. In: Recent Advances in Molecular Biology, Ed. Coelho, A.M. Springer-Verlag, Germany. (This is a refereed chapter with significant unpublished primary data from the lab).

Merianda, T. T., Botta, V., Bhat, K. M. (2005). Requirement of Patched reveals the role of pioneering neurons for the guidance of medial longitudinal tracts in the Drosophila ventral nerve cord. Dev. Genes Evoln. 215: 285-296.

Bhat, K. M. (2005). The primary role of Slit during the positioning of longitudinal tracts in the Drosophila nerve cord is to silence Netrin-mediated attraction. Genetics 170: 149-159.

Bhat, K. M., Apsel, N. (2004). Upregulation of Mitimere and Nubbin acts through CyclinE to confer self-renewing asymmetric division potential to neural precursor cells. Development 131: 1123-1134.

Yedvobnick, B., Kumar, A., Opraseuth, J., Mortimer, N., Bhat, K. M. (2004). The asymmetric division function of Mastermind is separable and distinct from its neurogenic function during Drosophila neurogenesis. Genetics 166:1281-1289.

Shyamala, B. V., Bhat, K. M. (2002). A Hedgehog independent Patched-Smoothened signaling activates Baboon/Activin pathway to regulate head morphogenesis in Drosophila. Development 129: 1839-1847.

Mehta, B., Bhat, K. M. (2001). Slit mediated signaling regulates the asymmetric localization of Inscuteable and promotes the terminal asymmetric division of secondary neuronal precursor cells in the Drosophila CNS. Development 128: 3161-3168.

Bhat, K. M., Van Beers, E., Bhat, P. (2000). sloppy paired acts as the downstream target of Wingless in the Drosophila CNS and interaction between sloppy paired and gooseberry inhibits sloppy paired during neurogenesis. Development 127: 655-665.

Wai, P., Truong, B., Bhat, K. M. (1999). Cell division genes promote asymmetric localization of determinants and interaction between Numb and Notch in the Drosophila CNS. Development 126: 2759-2770.

Bhat, K. M. (1999). The posterior determinant Nanos is required for the maintenance of adult germline stem cells during Drosophila oogenesis. Genetics 151: 1479-1492.

Bhat, K. M. (1999). Segmental genes and neuroblast specification and lineage elaboration in Drosophila. BioEssays 21: 472-485.

Bhat, K. M. (1998). frizzled and frizzled 2 play a partially redundant role in the Wingless signaling pathway and have similar functions to Wingless in neurogenesis. Cell 95: 1027-1036.

Bhat, K. M. (1998). Genetics of cell-cell signaling during neurogenesis: some answers and many questions. Int. J. Dev. Biol. 44: 127-140.

Bhat, K. M., Schedl. P (1997). Requirement for engrailed and invected genes reveals novel interactions between engrailed/invected, patched, gooseberry and wingless during Drosophila neurogenesis. Development 124: 1675-1688.

Bhat, K. M. Schedl, P (1997). Establishment of stem cell identity in the Drosophila germline. Dev. Dynamics 210: 371-382.

Bhat, K. M., Farkas, G., Karch, F., Gyurkovics, H., Gausz, J., Schedl, P. (1996). The Drosophila GAGA factor is required in the early embryo not only for transcriptional regulation but also for nuclear division. Development 122: 1113-1124.

Bhat, K. M. (1996). The patched signaling pathway mediates repression of gooseberry allowing neuroblast specification by wingless during Drosophila neurogenesis. Development 122: 2921- 2932.

Bhat, K. M., Poole, S. J., Schedl, P. (1995). The mitimere and pdm1 genes collaborate during the specification of the RP2/sib lineage in Drosophila neurogenesis. Mol. Cell. Biol. 15: 4052- 4063.

Bhat, K. M., Schedl. P. (1994). The Drosophila mitimere gene a member of the POU family is required for the specification of the RP2/sibling lineage during neurogenesis. Development 120:1501-1519.

Swift, F. K., Bhat, K. M., Younghusband, B., and Hamada. H. (1987). Characterization of a cell type specific enhancer element found in the human papilloma virus type 18 genome. EMBO J. 6: 1334-1339.

Bhat, K. M., McBurney, M.W., and Hamada, H. (1988). Functional cloning of mouse chromosomal loci specifically active in embryonal carcinoma stem cells. Mol. Cell. Biol. 8: 3251-3259.

Collaboration papers on Psychiatry and behavioral sciences:

Carta, M.G., Sancassiani, F., Pippia, V., Bhat, K.M., Sardu, C., Meloni, L. (2013). Alexithymia is associated with delayed treatment seeking in acute myocardial infarction. Psychotherapy and Psychosomatics 82(3):190-2. doi: 10.1159/000341181.

Carta, M.G, Sorbello, O, Moro, M.F, Bhat, K.M, Demelia, E, Serra, A, Mura, G, Sancassiani, F, Piga, M, Demelia, L. (2012). Bipolar disorders and Wilson's disease. BMC Psychiatry 12:52.

Carta, M.G., Bhat, K.M., Preti, A. (2012). GABAergic neuroactive steroids: a new frontier in bipolar disorders? Behavioral and Brain Functions. Behav Brain Funct. 8:61. doi: 10.1186/1744-9081-8-61.

Carta, M.G., Petretto D, Adamo S, Bhat K, M., Lecca M, Mura G, Carta V, Angermeyer M, Moro M. (2012). Counseling in primary care improves depression and quality of life. Clin Pract Epidemiol Ment Health. 8:152-7.

Carta, M.G, Mura, G, Lecca, M.E, Moro, M.F, Bhat, K.M, Angermeyer, M.C, Hardoy, M, Hakiskal, H.S Decreases in depression over 20 years in a mining area of Sardinia: Due to selective migration? (2012). J Affect Disord. May 8 (Epub ahead of print).

Mura, G, Bhat, K.M, Pisano, A, Licci, G, Carta, M. (2012). Psychiatric symptoms and quality of life in systemic sclerosis. Clin Pract Epidemiol Ment Health 8:67-73.

Mura, G., Donatella, R.P., Bhat, K. M. and Carta, M.G. (2012). Schizophrenia: from Epidemiology to Rehabilitation.  Clin Pract Epidemiol Ment Health. 8: 52-66.